Functional graft Poly(N-isopropyl acrylamide)s using reversible addition-fragmentation chain transfer (RAFT) polymerisation

被引：24

作者：

Carter, Steven R. ^{[1
]}

England, Richard M. ^{[1
]}

Hunt, Barry J. ^{[1
]}

Rimmer, Stephen ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Ctr Polymer, Polymer & Biomat Chem Labs, Sheffield S3 7HF, S Yorkshire, England

来源：

MACROMOLECULAR BIOSCIENCE | 2007年 / 7卷 / 08期

关键词：

graft copolymers; graft polymer; N-isopropyl acrylamide; RAFT; RAFT polymerization; stimulus responsive;

D O I：

10.1002/mabi.200700108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A series of NIPAM/4-vinyl benzyl chloride copolymers were substituted with 4(5)-imidazole dithioic acid or N-pyrrole dithioic acid to form multi-functional linear dithioate-functional polymers, which can be used as macromolecular transfer agents in a controlled radical polymerisation (RAFT) process. The presence of imidazole dithioate or N-pyrrole dithioate units along the NIPAM copolymer was determined by H-1 NMR, which showed broad CH-imidazole or CH-N-pyrrole resonances. Subsequent reaction of these multi-branch point polymers to produce graft polymers was achieved by reaction with NIPAM in the presence of AIBN. The graft polymers are produced as mixtures containing the desired product and linear polymer. The linear polymer is produced following transfer to the pendant dithioate group. Some of the branched polymers formed from the imidazole dithioate polymers were insoluble in water whilst others were found to be water soluble only in the presence of copper(II) ions. The use of N-pyrrole dithioate groups was found to substantially increase the solubility of the branched polymers in conventional solvents.

引用

页码：975 / 986

页数：12

共 27 条

[1]

Highly branched poly(N-isopropylacrylamide) for use in protein purification [J].