Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome - A systematic review and meta-analysis

被引:103
作者
Wille-Jorgensen, P
Jorgensen, LN [1 ]
Crawford, M
机构
[1] Univ Copenhagen, Bispebjerg Hosp, Dept Surg K, DK-2400 Copenhagen, Denmark
[2] Univ Copenhagen, Bispebjerg Hosp, Dept Anesthesiol, DK-2400 Copenhagen, Denmark
关键词
postthrombotic syndrome; deep vein thrombosis; surgery;
D O I
10.1160/TH04-09-0570
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Perioperative antithrombotic clinical regimens have reduced the incidence of postoperative deep venous thrombosis (DVT). Long-term effects of asymptomatic postoperative DVT have bee.-l studied in a number of clinical trials and the present review describes the clinical significance of asymptomatic postoperative DVT regarding the possible development of postthrombotic syndrome (PTS). We performed a systematic review of reference databases focusing upon studies including patients suspected of having postoperative DVT and reporting subsequent cases of PTS at the end of a well-defined follow-up period. The included studies were stratified according to type of screening method and applied statistics. Over-all evaluation included meta-analyses based upon the Cochrane software package. The overall relative risk of developing PTS was 1.58 (95% confidence intervals: 1.24-2.02) in patients suffering from asymptomatic DVT as compared to patients without DVT (p < 0.0005). In conclusion, asymptomatic postoperative DVT is associated with an increased risk of late development of PTS. The finding emphasizes that postoperative DVT diagnosed by means of well-defined objective measures, remains the correct scientific endpoint in trials evaluating the efficacy of preoperative antithrombotic treatment regimens.
引用
收藏
页码:236 / 241
页数:6
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