Clinical significance of lymph node micrometastasis of pN0 esophageal squamous cell carcinoma

被引：52

作者：

Matsumoto, M ^{[1
]}

Natsugoe, S ^{[1
]}

Nakashima, S ^{[1
]}

Sakamoto, F ^{[1
]}

Okumura, H ^{[1
]}

Sakita, H ^{[1
]}

Baba, M ^{[1
]}

Takao, S ^{[1
]}

Aikou, T ^{[1
]}

机构：

[1] Kagoshima Univ, Sch Med, Dept Surg 1, Kagoshima 8908520, Japan

来源：

CANCER LETTERS | 2000年 / 153卷 / 1-2期

关键词：

esophageal squamous cell carcinoma; lymph node micrometastasis; cytokeratin; postoperative recurrence; immunohistochemistry;

D O I：

10.1016/S0304-3835(00)00374-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The lymph nodes of 59 patients with pNO esophageal squamous cell carcinomas were examined immunohistochemically using cytokeratin (CK) antibody. Primary tumors were immunostained with cyclin D1 (CD1) and E-cadherin (E-cad) antibody. Lymph node micrometastasis (MM) was found in 39 (55.5%) patients. Tumor recurrence was found in 17 patients and all but one of them had MM. The 5-year survival rate was significantly poorer in patients with MM than in those without MM. Almost all patients with positive CD1 and negative E-cad expression had MM. The examination of CD1 and E-cad expression in primary tumors may be useful for predicting MM. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：189 / 197

页数：9

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