The enhancement of enantioselectivities for lipase-catalyzed reactions by using carbamates

被引：11

作者：

Lin, G ^{[1
]}

Lin, WY ^{[1
]}

Shieh, CT ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(98)02021-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselectivity of porcine pancreatic lipase-catalyzed resolution of 1-indanol was enhanced up to 3 fold in the presence of carbamates. The optimum incubation time for 4-nitrophenyl-N-hexyl carbamate and the enzyme was 18 h before this biocatalytic resolution. The optimum concentration of the inhibitor 4-nitrophenyl-N-hexyl carbamate in this resolution was 1 % mole equivalent of the substrate 1-indanol. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8881 / 8884

页数：4

共 28 条

[1]

Ammon R, 1931, BIOCHEM Z, V234, P54

[2]

Bamann E, 1930, BER DTSCH CHEM GES, V63, P394, DOI 10.1002/cber.19300630223

[3] GENERAL-ASPECTS AND OPTIMIZATION OF ENANTIOSELECTIVE BIOCATALYSIS IN ORGANIC-SOLVENTS - THE USE OF LIPASES [J].