The three yeast A kinases have specific signaling functions in pseudohyphal growth

被引:272
作者
Robertson, LS
Fink, GR
机构
[1] Whitehead Inst Biomed Res, Nine Cambridge Ctr, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
关键词
D O I
10.1073/pnas.95.23.13783
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The three yeast A kinase catalytic subunit isoforms are redundant for viability. We demonstrate that they have dramatically different roles in pseudohyphal development: Tpk2 is essential, whereas Tpk3 inhibits. Tpk1 has no discernible effect. Two-hybrid analysis identified the transcription factor Sfl1 as a protein that interacts specifically with Tpk2, but not Tpk1 or Tpk3. Deletion of SFL1 enhances pseudohyphal and invasive growth. Flo11, a cell surface flocculin required for pseudohyphal development, is transcriptionally regulated by Tpk2 and Sfl1. Genetic evidence indicates that Tpk2 acts upstream of Sfl1 in the regulation of Flo11.
引用
收藏
页码:13783 / 13787
页数:5
相关论文
共 22 条
[1]  
Ausubel F.A., 1997, CURRENT PROTOCOLS MO, DOI DOI 10.1.4
[2]   CAMP-INDEPENDENT CONTROL OF SPORULATION, GLYCOGEN-METABOLISM, AND HEAT-SHOCK RESISTANCE IN S-CEREVISIAE [J].
CAMERON, S ;
LEVIN, L ;
ZOLLER, M ;
WIGLER, M .
CELL, 1988, 53 (04) :555-566
[3]   CYCLIC-AMP DEPENDENT PROTEIN-KINASE PHOSPHORYLATES AND INACTIVATES THE YEAST TRANSCRIPTIONAL ACTIVATOR ADR1 [J].
CHERRY, JR ;
JOHNSON, TR ;
DOLLARD, C ;
SHUSTER, JR ;
DENIS, CL .
CELL, 1989, 56 (03) :409-419
[4]   Evolutionary origins and maintenance of redundant gene expression during metazoan development [J].
Cooke, J ;
Nowak, MA ;
Boerlijst, M ;
MaynardSmith, J .
TRENDS IN GENETICS, 1997, 13 (09) :360-364
[5]   UNIPOLAR CELL DIVISIONS IN THE YEAST SACCHAROMYCES-CEREVISIAE LEAD TO FILAMENTOUS GROWTH - REGULATION BY STARVATION AND RAS [J].
GIMENO, CJ ;
LJUNGDAHL, PO ;
STYLES, CA ;
FINK, GR .
CELL, 1992, 68 (06) :1077-1090
[6]   MULTIPLICITY OF AMINO ACID PERMEASES IN SACCHAROMYCES CEREVISIAE .I. EVIDENCE FOR A SPECIFIC ARGININE-TRANSPORTING SYSTEM [J].
GRENSON, M ;
MOUSSET, M ;
WIAME, JM ;
BECHET, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 127 (02) :325-+
[7]  
Guthrie C., 1991, GUIDE YEAST GENETICS
[8]  
James P, 1996, GENETICS, V144, P1425
[9]  
KENNELLY PJ, 1991, J BIOL CHEM, V266, P15555
[10]   ELEMENTS OF THE YEAST PHEROMONE RESPONSE PATHWAY REQUIRED FOR FILAMENTOUS GROWTH OF DIPLOIDS [J].
LIU, HP ;
STYLES, CA ;
FINK, GR .
SCIENCE, 1993, 262 (5140) :1741-1744