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Genomewide Association Studies and Assessment of the Risk of Disease

被引：1000
作者：
Manolio, Teri A. [1 ]
机构：
[1] NHGRI, Off Populat Genom, Bethesda, MD 20892 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 363卷 / 02期
关键词：
WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; COMMON VARIANTS; GENETIC-VARIANTS; PROSTATE-CANCER; CROHN-DISEASE; LARGE-SCALE; PREDICTION; COMPLEMENT; HERITABILITY;
D O I：
10.1056/NEJMra0905980
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Over the past 5 years, genomewide association studies have yielded a wealth of insight into genes and chromosomal loci that contribute to susceptibility to disease. This article, the second in the Genomic Medicine series, describes the design of these studies and considers the extent to which the data they provide are useful in predicting the risk of disease. Copyright © 2010 Massachusetts Medical Society.
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页码：166 / 176
页数：11
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