A concise enantioselective synthesis of antimalarial febrifugine alkaloids

被引：80

作者：

Ooi, H ^{[1
]}

Urushibara, A ^{[1
]}

Esumi, T ^{[1
]}

Iwabuchi, Y ^{[1
]}

Hatakeyama, S ^{[1
]}

机构：

[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 06期

关键词：

D O I：

10.1021/ol015655z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Reaction of (S)-2-(tert-butyldiphenylsilyloxy)-5-(mesyloxy)pentanal with hydroxylamine in allyl alcohol brought about simultaneous 1,3-dipolar cycloaddition of the resulting nitrone to allyl alcohol to give three diastereoisomeric adducts, from which (+)-febrifugine and (+)-isofebrifugine, potent antimalarial alkaloids, were synthesized.

引用

页码：953 / 955

页数：3

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