Structure and expression of fatty acid desaturases

被引：469

作者：

Los, DA

Murata, N ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Plant Physiol, Moscow, Russia

[2] Natl Inst Basic Biol, Okazaki, Aichi 444, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1998年 / 1394卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

acclimation; gene expression; gene regulation; fatty acid desaturase; lipid; membrane;

D O I：

10.1016/S0005-2760(98)00091-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fatty acid desaturases are enzymes that introduce double bonds into fatty acyl chains. They are present in all groups of organisms, i.e., bacteria, fungi, plants and animals, and play a key role in the maintenance of the proper structure and functioning of biological membranes. The desaturases are characterized by the presence of three conserved histidine tracks which are presumed to compose the Fe-binding active centers of the enzymes. Recent findings on the structure and expression of different types of fatty acid desaturase in cyanobacteria, plants and animals are reviewed in this article. Roles of individual desaturases in temperature acclimation and principles of regulation of the desaturase genes are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：3 / 15

页数：13

共 123 条

[1] The P-OLE1 gene of Pichia angusta encodes a Delta 9-fatty acid desaturase and complements the ole1 mutation of Saccharomyces cerevisiae [J].