FR207944, an antifungal antibiotic from Chaetomium sp no. 217 -: I.: Taxonomy, fermentation, and biological properties

被引：19

作者：

Kobayashi, M ^{[1
]}

Kanasaki, R ^{[1
]}

Sato, I ^{[1
]}

Abe, F ^{[1
]}

Nitta, K ^{[1
]}

Ezaki, M ^{[1
]}

Sakamoto, K ^{[1
]}

Hashimoto, M ^{[1
]}

Fujie, A ^{[1
]}

Hino, M ^{[1
]}

Hori, Y ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Fermentat Res Labs, Tsukuba, Ibaraki 3002698, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 03期

关键词：

FR207944; triterpene glucoside; FR901379; Chaetomium sp; Aspergillus fumigatus;

D O I：

10.1271/bbb.69.515

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus fumigatus and Candida albicans. Specifically, FR207944 exhibits in vitro and in vivo antifungal activity against A. famigatus. The effects of FR207944 on the morphology of A. fumigatus were shown to be similar to those of FR901379, a known 1,3-beta-glucan synthase inhibitor. The MECs of FR207944 against A. fumigatus FP1305 and C. albicans FP633 in micro-broth dilution test were 0.039 and 1.6 Kg/ml respectively. FR207944 showed good potency by subcutaneous injection and oral administration against A. fumigatus in a murine systemic infection model, with ED(50)s of 5.7 and 17mg/kg respectively.

引用

页码：515 / 521

页数：7

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