A scorpion neurotoxin increases the potency of a fungal insecticide

被引：161

作者：

Wang, Chengshu

St Leger, Raymond J. ^{[1
]}

机构：

[1] Univ Maryland, Dept Entomol, College Pk, MD 20742 USA

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China

来源：

NATURE BIOTECHNOLOGY | 2007年 / 25卷 / 12期

关键词：

D O I：

10.1038/nbt1357

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The low virulence of the insecticidal fungus Metarhizium anisopliae has stymied its widespread use in controlling insect pests. We show that high-level expression of an insect-specific neurotoxin from the scorpion Androctonus australis in hemolymph by M. anisopliae increases fungal toxicity 22-fold against tobacco hornworm ( Manduca sexta) caterpillars and ninefold against adult yellow fever mosquitoes ( Aedes aegypti) without compromising host specificity. Prelethal effects include reduced mobility and feeding of the insects targeted.

引用

页码：1455 / 1456

页数：2

共 15 条

[1] Engineering hypervirulence in a mycoherbicidal fungus for efficient weed control [J].