The neurobiology of zinc in health and disease

被引：1504

作者：

Frederickson, CJ

Koh, JY

Bush, AI

机构：

[1] NeuroBioTex Inc, Galveston, TX 77550 USA

[2] Univ Texas, Sch Med, Galveston, TX 77550 USA

[3] Univ Ulsan, Coll Med, Ctr Study CNS Zinc, Natl Creat Res Initiat,Dept Neurol, Seoul 138736, South Korea

[4] Univ Melbourne, Mental Hlth Res Inst Victoria, Oxidat Disorders Lab, Parkville, Vic 3052, Australia

[5] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia

[6] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Lab Oxidat Biol,Genet & Aging Res Unit, Boston, MA 02129 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 06期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/nrn1671

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for example, the Smith Papyrus(1)), and zinc has apparently been used fairly steadily throughout Roman(2) and modern times (for example, as the American lotion named for its zinc ore, 'Calamine'). It is, therefore, somewhat ironic that zinc is a relatively late addition to the pantheon of signal ions in biology and medicine. However, the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'.

引用

页码：449 / 462

页数：14

共 271 条

[1] Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release [J].