The master control gene for morphogenesis and evolution of the eye

被引：196

作者：

Gehring, WJ ^{[1
]}

机构：

[1] UNIV BASEL,BIOZENTRUM,CH-4056 BASEL,SWITZERLAND

来源：

GENES TO CELLS | 1996年 / 1卷 / 01期

关键词：

D O I：

10.1046/j.1365-2443.1996.11011.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The human Aniridia, the murine Small eye, and the eyeless mutations of Drosophila affect homologous (Pax-6) genes that contain both a paired- and a homeobox. By ectopic expression of these genes, functional eyes can be induced on the legs, wings, and antennae of the fly, indicating that eyeless (Pax-6) is the master control gene for eye morphogenesis. The finding of Pax-6 from flatworms to humans suggests that eyeless is a universal master control gene and that the various types of eyes in the various animal phyla may have evolved from a single prototype.

引用

页码：11 / 15

页数：5

共 19 条

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[2]

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[3]

GEHRING W, 1968, J EMBRYOL EXP MORPH, V20, P307

[4] INDUCTION OF ECTOPIC EYES BY TARGETED EXPRESSION OF THE EYELESS GENE IN DROSOPHILA [J].