共 44 条
IL-33-activated dendritic cells are critical for allergic airway inflammation
被引:259
作者:

Besnard, Anne-Gaelle
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Orleans, F-45071 Orleans 2, France
CNRS, UMR 6218, F-45071 Orleans, France Univ Orleans, F-45071 Orleans 2, France

Togbe, Dieudonnee
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Orleans, F-45071 Orleans 2, France
CNRS, UMR 6218, F-45071 Orleans, France
Artimmune SAS, Ctr Innovat, Orleans, France Univ Orleans, F-45071 Orleans 2, France

Guillou, Noelline
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Orleans, F-45071 Orleans 2, France
CNRS, UMR 6218, F-45071 Orleans, France Univ Orleans, F-45071 Orleans 2, France

Erard, Francois
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Orleans, F-45071 Orleans 2, France
CNRS, UMR 6218, F-45071 Orleans, France Univ Orleans, F-45071 Orleans 2, France

Quesniaux, Valerie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Orleans, F-45071 Orleans 2, France
CNRS, UMR 6218, F-45071 Orleans, France Univ Orleans, F-45071 Orleans 2, France

Ryffel, Bernhard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Orleans, F-45071 Orleans 2, France
CNRS, UMR 6218, F-45071 Orleans, France Univ Orleans, F-45071 Orleans 2, France
机构:
[1] Univ Orleans, F-45071 Orleans 2, France
[2] CNRS, UMR 6218, F-45071 Orleans, France
[3] Artimmune SAS, Ctr Innovat, Orleans, France
关键词:
Allergy;
Cytokines;
DC;
IL-33;
Lung inflammation;
HUMAN BASOPHILS;
MURINE MODEL;
IL-33;
RECEPTOR;
CYTOKINE;
EXPRESSION;
T1/ST2;
TYPE-2;
PROTEIN;
MEMBER;
D O I:
10.1002/eji.201041033
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
IL-33, a new member of the IL-1 family cytokine, is involved in Th2-type responses in a wide range of diseases and signals through the ST2 receptor expressed on many immune cells. Since the effects of IL-33 on DCs remain controversial, we investigated the ability of IL-33 to modulate DC functions in vitro and in vivo. Here, we report that IL-33 activates myeloid DCs to produce IL-6, IL-1 beta, TNF, CCL17 and to express high levels of CD40, CD80 OX40L and CCR7. Importantly, IL-33-activated DCs prime naive lymphocytes to produce the Th2 cytokines IL-5 and IL-13, but not IL-4. In vivo, IL-33 exposure induces DC recruitment and activation in the lung. Using an OVA-induced allergic lung inflammation model, we demonstrate that the reduced airway inflammation in ST2-deficient mice correlates with the failure in DC activation and migration to the draining LN. Finally, we show that adoptive transfer of IL-33-activated DCs exacerbates lung inflammation in a DC-driven model of allergic airway inflammation. These data demonstrate for the first time that IL-33 activates DCs during antigen presentation and thereby drives a Th2-type response in allergic lung inflammation.
引用
收藏
页码:1675 / 1686
页数:12
相关论文
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