Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver

被引：17

作者：

Ackerman, Zvi ^{[1
,2
]}

Oron-Herman, Mor ^{[3
,4
]}

Rosenthal, Talma ^{[3
]}

Pappo, Orit ^{[2
,5
]}

Link, Gabriela ^{[2
,6
]}

Sela, Ben-Ami ^{[3
,4
]}

Grozovski, Maria ^{[7
]}

机构：

[1] Hadassah Hebrew Univ, Med Ctr, Dept Med, IL-91240 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Sch Med, IL-91010 Jerusalem, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[4] Chaim Sheba Med Ctr, Inst Chem Pathol, IL-52621 Tel Hashomer, Israel

[5] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, IL-91240 Jerusalem, Israel

[6] Hebrew Univ Jerusalem, Sch Med, Dept Human Nutr & Metab, IL-91010 Jerusalem, Israel

[7] Ort Braude Coll Engn, Karmiel, Israel

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 03期

关键词：

malondialdehyde; alpha-tocopherol; paraoxonase; glutathione peroxidase and reductase; amlodipine; captopril; bezafibrate;

D O I：

10.1007/s10620-007-9911-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in alpha-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and alpha-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased alpha-tocopherol concentration and PON activity. Bezafibrate increased alpha-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu.

引用

页码：777 / 784

页数：8

共 58 条

[1] Fructose-induced fatty liver disease - Hepatic effects of blood pressure and plasma triglyceride reduction [J].

Ackerman, Z ;

Oron-Herman, M ;

Rosenthal, MGT ;

Pappo, O ;

Link, G ;

Sela, BA .

HYPERTENSION, 2005, 45 (05) :1012-1018

[2] Vitamins E and C for the treatment of NASH: Duplication of results but lack of demonstration of efficacy [J].

Adams, LA ;

Angulo, P .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (11) :2348-2350

[3] Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis [J].

Albano, E ;

Mottaran, E ;

Vidali, M ;

Reale, E ;

Saksena, S ;

Occhino, G ;

Burt, AD ;

Day, CP .

GUT, 2005, 54 (07) :987-993

[4] Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis [J].

Angulo, P ;

Keach, JC ;

Batts, KP ;

Lindor, KD .

HEPATOLOGY, 1999, 30 (06) :1356-1362

[5] Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: relationship with histopathologic severity [J].

Bahcecioglu, IH ;

Yalniz, M ;

Ilhan, N ;

Ataseven, H ;

Ozercan, IH .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (03) :318-323

[6]

BAKER H, 1980, NUTR REP INT, V21, P531

[7]

BEULTER E, 1975, RED CELL METABOLISM, P71

[8]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[9] Molecular mediators of hepatic steatosis and liver injury [J].

Browning, JD ;

Horton, JD .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (02) :147-152

[10]

CARLBERG I, 1985, METHOD ENZYMOL, V113, P484

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