Enantioselective total synthesis of cylindramide

被引：61

作者：

Cramer, N

Laschat, S

Baro, A

Schwalbe, H

Richter, C

机构：

[1] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany

[2] Univ Frankfurt, Inst Organ Chem & Chem Biol, Zentrum Biomol Magnet Resonanz, D-60439 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 05期

关键词：

macrolactams; tetramic acid; total syntheses;

D O I：

10.1002/anie.200461823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Key steps in the convergent enantio-selective synthesis of the cytotoxic natural products (see structural formula) are tandem Michael addition/electrophilic trapping reactions, Sonogashira coupling, Julia-Kocienski olefination, and macro-cyclization. Formation of the tetramic acid completed the synthesis.

引用

页码：820 / 822

页数：3

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