Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

被引：100

作者：

Asztalos, Bela F. ^{[1
]}

Swarbrick, Michael M. ^{[2
]}

Schaefer, Ernst J. ^{[1
]}

Dallal, Gerard E. ^{[1
]}

Horvath, Katalin V. ^{[1
]}

Ai, Masumi ^{[1
]}

Stanhope, Kimber L. ^{[2
,3
]}

Austrheim-Smith, Iselin ^{[4
]}

Wolfe, Bruce M. ^{[5
]}

Ali, Mohamed ^{[4
]}

Havel, Peter J. ^{[2
,3
]}

机构：

[1] Tufts Univ, Lipid Metab Lab, Human Nutr Res Ctr, Boston, MA 02111 USA

[2] Univ Calif Davis, Sch Med, Dept Mol Biosci, Davis, CA 95616 USA

[3] Univ Calif Davis, Sch Med, Sch Vet Med, Dept Nutr, Davis, CA 95616 USA

[4] Univ Calif Davis, Sch Med, Dept Surg, Davis, CA 95616 USA

[5] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

来源：

JOURNAL OF LIPID RESEARCH | 2010年 / 51卷 / 08期

关键词：

high density lipoprotein particles; cardiovascular disease risk; lipoprotein metabolism; glucose homeostasis; CHOLESTERYL ESTER TRANSFER; TRANSFER PROTEIN-ACTIVITY; INSULIN-RESISTANCE; BARIATRIC SURGERY; CARDIOVASCULAR RISK; HEART-DISEASE; PLASMA-LEVELS; SUBPOPULATIONS; ADIPONECTIN; MORTALITY;

D O I：

10.1194/jlr.P900015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were significantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, alpha-1 and alpha-2 levels were significantly lower. Over 1 year, significant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and pre beta-1 levels were observed with significant increases of HDL-C and alpha-1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol (P = 0.018) and LCAT mass (P = 0.011), but not with CETP mass (P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass (P = 0.005) and alpha-1 level (P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass (P = 0.043) and inversely with changes of alpha-1 (P = 0.03) and alpha-2 (P = 0.05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients.-Asztalos, B. F., M. M. Swarbrick, E. J. Schaefer, G. E. Dallal, K. V. Horvath, M. Ai, K. L. Stanhope, I. Austrheim-Smith, B. M. Wolfe, M. Ali, and P. J. Havel. Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women. J. Lipid Res. 51: 2405-2412.

引用

页码：2405 / 2412

页数：8

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