Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

被引：533

作者：

Wang, Weidong ^{[1
]}

机构：

[1] NIA, NIH, Baltimore, MD 21093 USA

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 10期

关键词：

D O I：

10.1038/nrg2159

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Fanconi anaemia (FA) has recently become an attractive model to study breast cancer susceptibility (BRCA) genes, as three FA genes, FANCD1, FANCN and FANCJ, are identical to the BRCA genes BRCA2, PALB2 and BRIP1. Increasing evidence shows that FA proteins function as signal transducers and DNA-processing molecules in a DNA-damage response network. This network consists of many proteins that maintain genome integrity, including ataxia telangiectasia and Rad3 related protein (ATR), Bloom syndrome protein (BLM), and BRCA1. Now that the gene that is defective in the thirteenth and last assigned FA complementation group (FANCI) has been identified, I discuss what is known about FA proteins and their interactive network, and what remains to be discovered.

引用

页码：735 / 748

页数：14

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