An enantiocontrolled synthesis of a key intermediate to (+)-lactacystin

被引：40

作者：

Kang, SH ^{[1
]}

Jun, HS ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 18期

关键词：

D O I：

10.1039/a804954h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An asymmetric synthesis of a key intermediate 16 to (+)-lactacystin 1 has been established starting from epoxide 2 via intramolecular mercurioamidation of allylic trichloroacetimidate 4 and concomitant addition-reduction of ester 13 by Pr-i MgBr, in which reduction of the intermediate ketone proceeded with complete stereoselectivity.

引用

页码：1929 / 1930

页数：2

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