DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system

被引：8

作者：

Deuter, R

Linz, J

Pietsch, S

Winde, G

Hentsch, S

Muller, O

机构：

[1] MAX PLANCK INST MOL PHYSIOL,ARBEITSGRP TUMORGENET,D-44139 DORTMUND,GERMANY

[2] STADT KLINIKEN,CHIRURG KLIN,D-44137 DORTMUND,GERMANY

[3] UNIV MUNSTER,CHIRURG UNIV KLIN,D-48149 MUNSTER,GERMANY

[4] RUHR UNIV BOCHUM,ST JOSEF HOSP,CHIRURG KLIN,D-44791 BOCHUM,GERMANY

来源：

CANCER LETTERS | 1996年 / 109卷 / 1-2期

关键词：

colorectal carcinogenesis; tumor progression; microsatellite instability; TNM classification of malignant tumors;

D O I：

10.1016/S0304-3835(96)04441-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood, normal and tumor tissue samples of 23 patients with sporadic colorectal tumors were screened for DNA alterations in the tumor relevant genes APC, K-ras, DCC and p53. Six different microsatellite regions were analyzed for instability by a new developed non-radioactive method. Somatic DNA alterations were found in 17 tumor samples: 13 carried single or multiple changes in single genes; six carried alterations in microsatellites; two tumors showed tumor suppressor gene mutations in addition to microsatellite changes. We found no indications of correlations between current genetic models of colorectal tumor progression and the established TNM system for histopathological tumor classification.

引用

页码：161 / 169

页数：9

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