Capsaicin suppresses phorbol ester-induced activation of NF-κB/Rel and AP-1 transcription factors in mouse epidermis

被引：93

作者：

Han, SS ^{[1
]}

Keum, YS ^{[1
]}

Seo, HJ ^{[1
]}

Chun, KS ^{[1
]}

Lee, SS ^{[1
]}

Surh, YJ ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

CANCER LETTERS | 2001年 / 164卷 / 02期

关键词：

capsaicin; NF-kappa B; activator protein 1; transcription factor; mouse skin carcinogenesis; tumor promotion;

D O I：

10.1016/S0304-3835(01)00378-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Capsaicin, the principal pungent ingredient of hot chili peppers, has anti-inflammatory and analgesic properties and is currently used as a topical cream for the management of various neuropathic conditions. In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of I kappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65. Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment. Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：119 / 126

页数：8

共 41 条

[1] REDOX REGULATION OF FOS AND JUN DNA-BINDING ACTIVITY INVITRO [J].