Strong, specific, reversible binding ligands for transfer RNA: Comparison by fluorescence and NMR spectroscopies with distamycin binding for a new structural class of ligand

被引：9

作者：

Bichenkova, EV ^{[1
]}

Sadat-Ebrahimi, SE ^{[1
]}

Wilton, AN ^{[1
]}

O'Toole, N ^{[1
]}

Marks, DS ^{[1
]}

Douglas, KT ^{[1
]}

机构：

[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 9-11期

关键词：

D O I：

10.1080/07328319808004698

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Binding data are presented for the interaction with brewer's yeast tRNA(Phe) Of a new structural family of ligands, symmetrical 'bis-benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNA(Phe) when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.

引用

页码：1651 / 1665

页数：15

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