Lysophosphatidic acid-induced interleukin-1β expression is mediated through Gi/Rho and the generation of reactive oxygen species in macrophages

被引：31

作者：

Chang, Chi-Lun ^{[2
]}

Lin, Mu-En ^{[2
]}

Hsu, Hsien-Yeh ^{[3
]}

Yao, Chao-Ling ^{[4
]}

Hwang, Shiaw-Min ^{[4
]}

Pan, Chien-Yuan ^{[1
,2
]}

Hsu, Chi-Yen ^{[2
]}

Lee, Hsinyu ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Dept Life Sci, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Inst Zool, Taipei 106, Taiwan

[3] Natl Yang Ming Univ, Inst Biotechnol Med, Taipei 112, Taiwan

[4] Food Ind Res & Dev Ctr, Bioresource Collect & Res Ctr, Hsinchu, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2008年 / 15卷 / 03期

关键词：

LPA; macrophage; IL-1; beta; ROS; inflammation;

D O I：

10.1007/s11373-007-9223-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysophophatidic acid (LPA), a low-molecular-weight lysophospholipid enriched in platelets and mildly oxidized low-density lipoproteins, is known to regulate inflammation and atherosclerosis by binding to its cognate receptors. In this study, we reported that LPA upregulated interleukin-1 beta (IL-1 beta) expression in mouse J774A.1 macrophages. By using pharmacological inhibitors, it was suggested that G(i)/Rho activation and subsequent reactive oxygen species (ROS) production were involved in IL-1 beta induction. In addition, IL-1 beta induction by LPA was also observed in human primary macrophages. In summary, LPA is involved in the processes of inflammation by affecting macrophage behavior.

引用

页码：357 / 363

页数：7

共 34 条

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