Exploring new instrumentation parameters for electrochemotherapy - Attacking tumors with bursts of biphasic pulses instead of single pulses

Electrochemotherapy using rectangular biphasic stimuli and bursts of stimuli, as compared to using monophasic pulses, are at least of the same efficacy. The use of small surface electrodes in dermatological treatment yields electrode-skin impedances in the range of 200-400 ohms, with the impedances being almost entirely resistive. The use of a single burst of 50+50 μsec biphasic pulses, with an overall duration of about 7 msec, is well tolerated by patients, causing just one short stimulus sensation instead of a succession of eight stimuli.