Cytotoxicity of nanoparticle-loaded polymer capsules

被引：109

作者：

Kirchner, C

Javier, AM

Susha, AS

Rogach, AL

Kreft, O

Sukhorukov, GB

Parak, WJ ^{[1
]}

机构：

[1] Univ Munich, Dept Phys, D-80799 Munich, Germany

[2] Univ Munich, Ctr Nanosci, CeNS, D-80799 Munich, Germany

[3] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany

来源：

TALANTA | 2005年 / 67卷 / 03期

关键词：

cytotoxicity; nanoparticle; polymer capsule;

D O I：

10.1016/j.talanta.2005.06.042

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cytotoxic effects of micrometer- sized polymer capsules composed out of alternating layers of polystyrenesuffonate (PSS) and polyallylamine hydrochloride (PAH) on a fibroblast cell line have been investigated with an adhesion assay. For the purpose of visualization with fluorescence nanometer-sized CdTe nanoparticles have been embedded in the walls of the capsules. Similar to free CdTe nanoparticles, toxic Cd-ions are also released from CdTe nanoparticles that have been embedded in capsules. At high capsule concentrations, the capsules start to sediment on top of the cells and thus impair cell viability. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：486 / 491

页数：6

共 43 条

[1] Magnetic drug targeting - Biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment [J].