Virological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfection

被引：11

作者：

Angel, JB ^{[1
]}

Hu, YW

Kravcik, S

Tsui, R

Lee, KH

Barbour, J

Balaskas, E

Branson, BM

Delwart, EL

Grant, RM

机构：

[1] Univ Ottawa, Ottawa Hlth Res Inst, Ottawa, ON, Canada

[2] Univ Ottawa, Ottawa Hosp, Ottawa, ON, Canada

[3] Canadian Blood Serv, Ottawa, ON, Canada

[4] Univ Calif San Francisco, San Francisco, CA 94143 USA

[5] Blood Ctr Pacific, San Francisco, CA USA

[6] Gladstone Inst Virol & Immunol, San Francisco, CA USA

[7] Ctr Dis Control, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA

来源：

AIDS | 2004年 / 18卷 / 02期

关键词：

D O I：

10.1097/00002030-200401230-00027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An HIV-1-infected man who experienced rapid disease progression and poor response to therapy after starting a new sexual relationship with an infected partner is known as the 'Ottawa super infection case'. Subsequent analysis of viral sequences of protease, reverse transcriptase, Gag p17, and Env V3 provided no evidence for the acquisition of genetically divergent viruses before disease progression or drug resistance during virological failure of combination therapy. Whether HIV-1 superinfection contributes to disease progression or the spread of drug-resistant HIV-1 remains unknown.

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页码：331 / 334

页数：4

相关论文

共 16 条

[1] HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus [J].

Altfeld, M ;

Allen, TM ;

Yu, XG ;

Johnston, MN ;

Agrawal, D ;

Korber, BT ;

Montefiori, DC ;

O'Connor, DH ;

Davis, BT ;

Lee, PK ;

Maier, EL ;

Harlow, J ;

Goulder, PJR ;

Brander, C ;

Rosenberg, ES ;

Walker, BD .

NATURE, 2002, 420 (6914) :434-439

[2]

ANGEL JB, 2000, 7 C RETR OPP INF SAN

[3] Human immunodeficiency virus superinfection and recombination: Current state of knowledge and potential clinical consequences [J].

Blackard, JT ;

Cohen, DE ;

Mayer, KH .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (08) :1108-1114

[4]

DAAR ES, 2002, 9 C RETR OPP INF SEA

[5] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EVOLUTION IN-VIVO TRACKED BY DNA HETERODUPLEX MOBILITY ASSAYS [J].

DELWART, EL ;

SHEPPARD, HW ;

WALKER, BD ;

GOUDSMIT, J ;

MULLINS, JI .

JOURNAL OF VIROLOGY, 1994, 68 (10) :6672-6683

[6] Natural history of serum HIV-1 RNA levels in 330 patients with a known date of infection [J].

Hubert, JB ;

Burgard, M ;

Dussaix, E ;

Tamalet, C ;

Deveau, C ;

Le Chenadec, J ;

Chaix, ML ;

Marchadier, E ;

Vildé, JL ;

Delfraissy, JF ;

Meyer, L ;

Rouzioux, C .

AIDS, 2000, 14 (02) :123-131

[7] A patient with HIV-1 superinfection [J].

Jost, S ;

Bernard, MC ;

Kaiser, L ;

Yerly, S ;

Hirschel, B ;

Samri, A ;

Autran, B ;

Goh, LE ;

Perrin, L .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (10) :731-736

[8] Clade BHIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus [J].

Koelsch, KK ;

Smith, DM ;

Little, SJ ;

Ignacio, CC ;

Macaranas, TR ;

Brown, AJL ;

Petropoulos, CJ ;

Richman, DD ;

Wong, JK .

AIDS, 2003, 17 (07) :F11-F16

[9] EVOLUTION OF THE V3 ENVELOPE DOMAIN IN PROVIRAL SEQUENCES AND ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DURING TRANSITION OF THE VIRAL BIOLOGICAL PHENOTYPE [J].

KUIKEN, CL ;

DEJONG, JJ ;

BAAN, E ;

KEULEN, W ;

TERSMETTE, M ;

GOUDSMIT, J .

JOURNAL OF VIROLOGY, 1992, 66 (07) :4622-4627

[10] Longitudinal human immunodeficiency virus type 1 load in the Italian seroconversion study: Correlates and temporal trends of virus load [J].

Lyles, CM ;

Dorrucci, M ;

Vlahov, D ;

Pezzotti, P ;

Angarano, G ;

Sinicco, A ;

Alberici, F ;

Alcorn, TM ;

Vella, S ;

Rezza, G .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (04) :1018-1024