Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza Bunge

被引：74

作者：

Lee, SY ^{[1
]}

Choi, DY ^{[1
]}

Woo, ER ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Salvia miltiorrhiza; Labiatae; tanshinones; osteoclast differentiation;

D O I：

10.1007/BF02973876

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We screened natural products to find compounds with anti-osteoporotic potential using a coculture-based system by which osteoclast differentiation is effectively achieved. We found that methylene chloride soluble fraction of the root of Salvia miltiorrhiza Bunge (Labiatae) suppressed osteoclast differentiation. Five tanshinones, tanshinone IIA (1), tanshinone 1 (2), cryptotanshinone (3), 15,16-dihydrotanshinone I (4), and ferruginol (5) were subsequently isolated from fraction. Among the five compounds, compounds 1-4 reduced the formation of TRAP-positive multinuclear osteoclasts. These results suggest that the identified tanshinones may be useful candidates for development of therapeutic agents to treat osteoporosis and other bone-resorptive diseases.

引用

收藏

页码：909 / 913

页数：5

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