Pathogenesis of the antiphospholipid antibody syndrome

被引：27

作者：

Lockshin, MD

机构：

来源：

LUPUS | 1996年 / 5卷 / 05期

关键词：

antiphospholipid antibody; beta(2)-glycoprotein-I; endothelium; platelets; placenta;

D O I：

10.1177/096120339600500514

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternative hypotheses about thrombogenicity which relegate aPL to the role of bystander have not yet been excluded.

引用

收藏

页码：404 / 408

页数：5

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