IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis

被引：46

作者：

Bettelli, E

Nicholson, LB

Kuchroo, VK

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2003年 / 20卷 / 04期

关键词：

D O I：

10.1016/S0896-8411(03)00048-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

引用

页码：265 / 267

页数：3

共 29 条

[1]

In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[2]

Bettelli E, 1998, J IMMUNOL, V161, P3299

[3]

Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo [J].

Buer, J ;

Lanoue, A ;

Franzke, A ;

Garcia, C ;

von Boehmer, H ;

Sarukhan, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) :177-183

[4]

Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10 [J].

Burkhart, C ;

Liu, GY ;

Anderton, SM ;

Metzler, B ;

Wraith, DC .

INTERNATIONAL IMMUNOLOGY, 1999, 11 (10) :1625-1634

[5]

Cannella B, 1996, J NEUROSCI RES, V45, P735, DOI 10.1002/(SICI)1097-4547(19960915)45:6<735::AID-JNR10>3.0.CO

[6]

2-V

[7]

REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS [J].

CHEN, YH ;

KUCHROO, VK ;

INOBE, J ;

HAFLER, DA ;

WEINER, HL .

SCIENCE, 1994, 265 (5176) :1237-1240

[8]

Different therapeutic outcomes in experimental allergic encephalomyelitis dependant upon the mode of delivery of IL-10: A comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system [J].

Croxford, JL ;

Feldmann, M ;

Chernajovsky, Y ;

Baker, D .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :4124-4130

[9]

Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis [J].

Cua, DJ ;

Groux, H ;

Hinton, DR ;

Stohlman, SA ;

Coffman, RL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06) :1005-1010

[10]

Central nervous system expression of IL-10 inhibits autoimmune encephalomyelitis [J].

Cua, DJ ;

Hutchins, B ;

LaFace, DM ;

Stohlman, SA ;

Coffman, RL .

JOURNAL OF IMMUNOLOGY, 2001, 166 (01) :602-608

← 1 2 3 →