Increase of sural nerve T cells in progressive axonal polyneuropathy and monoclonal gammopathy

被引：9

作者：

Eurelings, M ^{[1
]}

van den Berg, LH ^{[1
]}

Wokke, JHJ ^{[1
]}

Franssen, H ^{[1
]}

Vrancken, AFJE ^{[1
]}

Notermans, NC ^{[1
]}

机构：

[1] Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Neurol, NL-3508 GA Utrecht, Netherlands

来源：

NEUROLOGY | 2003年 / 61卷 / 05期

关键词：

D O I：

10.1212/01.WNL.0000078103.71192.40

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated whether T cells have a role in the pathogenesis of axonal polyneuropathy and monoclonal gammopathy by comparing the presence of T cells in sural nerves of 23 patients with axonal polyneuropathy and monoclonal gammopathy (12 IgM, 11 IgG), of 15 patients with chronic idiopathic axonal polyneuropathy, and of 10 autopsy cases. Seven patients with an increased T-cell density had a progressive disease course, and four of these patients were treated with prednisone with a good response, suggesting that vasculitis plays a role in the pathogenesis.

引用

页码：707 / 709

页数：3

共 10 条

[1] The diagnostic value of sural nerve T cells in chronic inflammatory demyelinating polyneuropathy [J].

Bosboom, WMJ ;

Van den Berg, LH ;

De Boer, L ;

Van Son, MJ ;

Veldman, H ;

Franssen, H ;

Logtenberg, T ;

Wokke, JHJ .

NEUROLOGY, 1999, 53 (04) :837-845

[2] NONSYSTEMIC VASCULITIC NEUROPATHY [J].

DYCK, PJ ;

BENSTEAD, TJ ;

CONN, DL ;

STEVENS, JC ;

WINDEBANK, AJ ;

LOW, PA .

BRAIN, 1987, 110 :843-854

[3]

Eurelings M, 2002, ACTA NEUROPATHOL, V103, P107

[4] AXONAL NEUROPATHY IN A PATIENT WITH IGM M-PROTEIN REACTIVE WITH NERVE ENDONEURIUM [J].

FREDDO, L ;

HAYS, AP ;

SHERMAN, WH ;

LATOV, N .

NEUROLOGY, 1985, 35 (09) :1321-1325

[5] Dominant T-cell clones of unknown significance in patients with idiopathic sensory neuropathies [J].

Gherardi, RK ;

Farcet, JP ;

Créange, A ;

Claudepierre, P ;

Malapert, D ;

Authier, FJ ;

Delfau-Larue, MH .

NEUROLOGY, 1998, 51 (02) :384-389

[6] PLASMA-CELL DYSCRASIA AND PERIPHERAL NEUROPATHY WITH A MONOCLONAL-ANTIBODY TO PERIPHERAL-NERVE MYELIN [J].

LATOV, N ;

SHERMAN, WH ;

NEMNI, R ;

GALASSI, G ;

SHYONG, JS ;

PENN, AS ;

CHESS, L ;

OLARTE, MR ;

ROWLAND, LP ;

OSSERMAN, EF .

NEW ENGLAND JOURNAL OF MEDICINE, 1980, 303 (11) :618-621

[7] ANTIBODIES TO SULFATIDE AND TO CHONDROITIN SULFATE-C IN PATIENTS WITH CHRONIC SENSORY NEUROPATHY [J].

NEMNI, R ;

FAZIO, R ;

QUATTRINI, A ;

LORENZETTI, I ;

MAMOLI, D ;

CANAL, N .

JOURNAL OF NEUROIMMUNOLOGY, 1993, 43 (1-2) :79-85

[8] CRYOGLOBULINEMIC NEUROPATHY - A CLINICAL, MORPHOLOGICAL AND IMMUNOCYTOCHEMICAL STUDY OF 8 CASES [J].

NEMNI, R ;

CORBO, M ;

FAZIO, R ;

QUATTRINI, A ;

COMI, G ;

CANAL, N .

BRAIN, 1988, 111 :541-552

[9] POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE - A PROSPECTIVE-STUDY OF THE PROGNOSTIC VALUE OF CLINICAL AND LABORATORY ABNORMALITIES [J].

NOTERMANS, NC ;

WOKKE, JHJ ;

LOKHORST, HM ;

FRANSSEN, H ;

VANDERGRAAF, Y ;

JENNEKENS, FGI .

BRAIN, 1994, 117 :1385-1393

[10] Chronic idiopathic axonal polyneuropathy - Comparison of patients with and without monoclonal gammopathy [J].

Notermans, NC ;

Wokke, JHJ ;

vandenBerg, LH ;

vanderGraaf, Y ;

Franssen, H ;

Teunissen, LL ;

Lokhorst, HM .

BRAIN, 1996, 119 :421-427

← 1 →