Paper - a potential platform in pharmaceutical development

被引：66

作者：

Chen, Yi-Hsun ^{[1
,2
]}

Kuo, Zong-Keng ^{[1
,3
]}

Cheng, Chao-Min ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Inst Nanoengn & Microsyst, Hsinchu 300, Taiwan

[2] Ind Technol Res Inst, Biomed Technol & Device Res Labs, Ctr Excellence Drug Dev, Pharmacokinet Technol Dept, Hsinchu 300, Taiwan

[3] Ind Technol Res Inst, Biomed Technol & Device Res Labs, Ctr Excellence Drug Dev, Pharmacodynam Technol Dept, Hsinchu 300, Taiwan

来源：

TRENDS IN BIOTECHNOLOGY | 2015年 / 33卷 / 01期

关键词：

bioassay; diagnostics; paper-based microfluidic device; point-of-care diagnostics; clinically based diagnostics in hospital; translational medicine; MICROFLUIDIC DEVICES; DRUG DISCOVERY; ELISA; ASSAYS; COST; IMMUNOASSAY; DIAGNOSTICS; CULTURES; URINE; TAPE;

D O I：

10.1016/j.tibtech.2014.11.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Paper is predominantly composed of cellulose fibers that have an inherent ability to wick fluids by capillary action; it provides an interesting diagnostic platform that is inexpensive, easily obtained, and eco-friendly. Paper has been used in various types of biologically relevant applications including paper-based molecular assays, paper-based ELISA (P-ELISA), paper-based nucleic acid assays, and paper-based cell assays. Based on recent successes with the use of paper as a platform, we contend that paper is not only very suitable for diagnostics but could provide a more advantageous platform than current plastics-based platforms for drug discovery, and would be useful for accomplishing in vitro pre-compound screening steps while offering a possible solution to several economic obstacles inherent in the pharmaceutical industry.

引用

页码：4 / 9

页数：6

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