Monitoring of antisolvent addition crystallization with Raman spectroscopy

被引：14

作者：

Falcon, JA

Berglund, KA ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA

[3] Michigan State Univ, Dept Agr Engn, E Lansing, MI 48824 USA

[4] Univ Lulea, Div Biochem & Chem Proc Engn, SE-97187 Lulea, Sweden

来源：

CRYSTAL GROWTH & DESIGN | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1021/cg0340446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fiber optic Raman spectroscopy was used for in situ monitoring of antisolvent addition crystallization of cortisone acetate. Raman spectral features of the solvent, the antisolvent, and the solute were monitored to measure the relative concentration of the components. Different rates of antisolvent addition were monitored and the resulting solid-state form was characterized using Raman spectroscopy and DSC. Raman spectroscopy was used to monitor dehydration during storage of the product crystals. The current study demonstrates the advantages of using Raman spectroscopy to monitor the solution phase during crystallization and simultaneously monitoring the solid-state form.

引用

页码：947 / 952

页数：6

共 20 条

[1] A fiber optic probe for monitoring protein aggregation, nucleation and crystallization [J].