Campylobacter jejuni induces secretion of proinflammatory chemokines from human intestinal epithelial cells

被引：43

作者：

Hu, L ^{[1
]}

Hickey, TE ^{[1
]}

机构：

[1] Naval Med Res Ctr, Enteri Dept, Silver Spring, MD 20910 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 07期

关键词：

D O I：

10.1128/IAI.73.7.4437-4440.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Campylobacter jejuni is a common cause of diarrhea in humans. While the pathogenic mechanisms of Cjejuni are not completely understood, host inflammatory responses are thought to be contributing factors. In this report, C. jejuni 81-176 is shown to up-regulate chemokines essential to inflammatory responses. Growth-related oncogene alpha (GRO alpha), GRO gamma, macrophage inflammatory protein 1, monocyte chemoattractant protein 1 (MCP-1), and gamma interferon-inducible protein 10 (gamma IP-10) mRNA transcription in INT-407 cells was enhanced within 4 h of bacterial exposure. Infection with viable campylobacters was necessary for sustained chemokine transcription and was NF-kappa B dependent. GRO alpha, gamma IP-10, and MCP-1 chemokine secretions were confirmed by immunological assays.

引用

页码：4437 / 4440

页数：4

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