Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population

被引：27

作者：

Iwasaki, N

Horikawa, Y

Tsuchiya, T

Kitamura, Y

Nakamura, T

Tanizawa, Y

Oka, Y

Hara, K

Kadowaki, T

Awata, T

Honda, M

Yamashita, K

Oda, N

Yu, L

Yamada, N

Ogata, M

Kamatani, N

Iwamoto, Y

del Bosque-Plata, L

Hayes, MG

Cox, NJ

Bell, GI

机构：

[1] Tokyo Womens Med Univ, Ctr Diabet, Shinjuku Ku, Tokyo 1628666, Japan

[2] Gunma Univ, Inst Mol & Cellular Regulat, Dept Cell Biol, Mol Genet Lab, Maebashi, Gumma 371, Japan

[3] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[5] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[6] Tokyo Womens Med Univ, Inst Rheumatol, Dept Stat Genet, Tokyo, Japan

[7] Yamaguchi Univ, Grad Sch Med, Dept Biosignal Anal, Div Mol Anal Human Disorders, Ube, Yamaguchi 755, Japan

[8] Tohoku Univ, Dept Internal Med, Div Mol Metab & Diabet, Sendai, Miyagi 980, Japan

[9] Univ Tokyo, Grad Sch Med, Dept Metab Dis, Tokyo, Japan

[10] Univ Tokyo, Fac Med, Tokyo 113, Japan

[11] Saitama Med Sch, Dept Med, Div Endocrinol & Diabet, Saitama, Japan

[12] Shiseikai Daini Hosp, Tokyo, Japan

[13] Seijin Igaku Med Clin, Tokyo, Japan

[14] Fujita Hlth Univ, Sch Med, Dept Internal Med, Aichi, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2005年 / 50卷 / 02期

关键词：

association study; age-at-diagnosis; calpain-10; genetics; polymorphism; type; 2; diabetes;

D O I：

10.1007/s10038-004-0225-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/ 221 haplogenotype ( odds ratio ( OR) = 3.53, P= 0.02). However, strati. cation based on the median age-at-diagnosis in the pooled study population (< 50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥ 50 years OR = 0.82 and 0.80, respectively; P = 0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.

引用

页码：92 / 98

页数：7

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