Self-organizing molecular networks

被引：18

作者：

Stange, P

Zanette, D

Mikhailov, A

Hess, B

机构：

[1] Max Planck Inst Med Forsch, D-69120 Heidelberg, Germany

[2] Max Planck Gesell, Fritz Haber Inst, Phys Chem Abt, D-14195 Berlin, Germany

[3] Ctr Atom Bariloche, Consejo Nacl Invest Cient & Tecn, RA-8400 Bariloche, Rio Negro, Argentina

[4] Inst Balseiro, RA-8400 Bariloche, Rio Negro, Argentina

来源：

BIOPHYSICAL CHEMISTRY | 1998年 / 72卷 / 1-2期

关键词：

enzymic reactions; allosteric regulation; diffusion; synchronization; microvolumes;

D O I：

10.1016/S0301-4622(98)00124-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Strong diffusional mixing and short delivery times typical for micrometer and sub-micrometer reaction volumes lead to a special situation where the turnover times of individual enzyme molecules become the largest characteristic time scale of the chemical kinetics. Under these conditions, populations of cross-regulating allosteric enzymes form molecular networks that exhibit various kinds of self-organized coherent collective dynamics. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：73 / 85

页数：13

共 20 条

[1]

Adam G., 1968, Structural Chemistry and Molecular Biology

[2]

Berg H. C., 1983, RANDOM WALKS BIOL

[3]

Blumenfeld LA., 1994, BIOPHYSICAL THERMODY, DOI [10.1007/978-1-4612-2630-7, DOI 10.1007/978-1-4612-2630-7]

[4] *UBER DIE KINETIK SEHR SCHNELL VERLAUFENDER IONENREAKTIONEN IN WASSERIGER LOSUNG [J].

EIGEN, M .

ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-FRANKFURT, 1954, 1 (3-4) :176-200

[5]

Goldbeter A., 1996, BIOCH OSCILLATIONS C

[6]

Gutfreund H., 1995, Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts

[7] SELF-ORGANIZATION IN LIVING CELLS [J].

HESS, B ;

MIKHAILOV, A .

BERICHTE DER BUNSEN-GESELLSCHAFT-PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 1994, 98 (09) :1198-1201

[8] Transition from molecular chaos to coherent spiking of enzymic reactions in small spatial volumes [J].

Hess, B ;

Mikhailov, A .

BIOPHYSICAL CHEMISTRY, 1996, 58 (03) :365-368

[9] SELF-ORGANIZATION IN LIVING CELLS [J].

HESS, B ;

MIKHAILOV, A .

SCIENCE, 1994, 264 (5156) :223-224

[10] MICROSCOPIC SELF-ORGANIZATION IN LIVING CELLS - A STUDY OF TIME MATCHING [J].

HESS, B ;

MIKHAILOV, A .

JOURNAL OF THEORETICAL BIOLOGY, 1995, 176 (01) :181-184

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