Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine

被引：7

作者：

Bazin, Marc J.

Shi, Helen

Delaney, Jeannine

Kline, Billie

Zhu, Zhendong

Kuhn, Cyrille

Berlioz, Francoise

Farley, Kathleen A.

Fate, Gwen

Lam, Wing

Walker, Gregory S.

Yu, Linning

Pollastri, Michael P.

机构：

[1] Pfizer Res Technol Ctr, Cambridge, MA 02139 USA

[2] Pfizer Ann Arbor Labs, Ann Arbor, MI 48105 USA

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2007年 / 70卷 / 04期

关键词：

metabolism; metalloporphyrin; oxidation;

D O I：

10.1111/j.1747-0285.2007.00568.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Major metabolites of dimethylaminoantipyrine have been synthesized using iron ortho-nitrophenylporphyrin chloride as biomimetic catalyst. Reactivity of iron tetrakis-ortho-nitrophenylporphyrin chloride [Fe(TNO2PP)Cl] has been compared with iron tetrakis-pentafluorophenylporphyrin chloride and iron tetrakis-2,6-dichlorophenylporphyrin chloride using various oxidants such as hydrogen peroxide, iodosobenzene, and cumene hydroperoxide in either protic or aprotic solvent. Effect of imidazole has been showed on the reactivity of Fe(TNO2PP)Cl/cumene hydroperoxide system.

引用

页码：354 / 359

页数：6

共 13 条

[1]

METABOLISM OF AMINOPYRINE AND DERIVATIVES IN MAN - IN-VIVO STUDY OF MONOMORPHIC AND POLYMORPHIC METABOLIC PATHWAYS [J].