Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesis

被引：39

作者：

Letouze, Eric ^{[1
,2
,3
]}

Allory, Yves ^{[4
,5
]}

Bollet, Marc A. ^{[6
]}

Radvanyi, Francois ^{[2
,3
]}

Guyon, Frederic ^{[1
]}

机构：

[1] Univ Paris Diderot Paris 7, INSERM, UMR S 973, MTi, F-75205 Paris 13, France

[2] Ctr Rech, Inst Curie, F-75248 Paris, France

[3] CNRS, UMR 144, F-75248 Paris 05, France

[4] INSERM, U955, F-94000 Creteil, France

[5] Grp Hosp Albert Chenevier Henri Mondor, AP HP, Dept Pathol, F-94000 Creteil, France

[6] Inst Curie, Dept Oncol Radiotherapie, F-75248 Paris 05, France

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 07期

关键词：

COMPARATIVE GENOMIC HYBRIDIZATION; BLADDER-CANCER; GENETIC ALTERATIONS; UROTHELIAL CANCER; MONOCLONAL ORIGIN; CLONAL EVOLUTION; CHROMOSOME; 11Q13; TREE MODELS; DNA; RECONSTRUCTION;

D O I：

10.1186/gb-2010-11-7-r76

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We present a computational method, TuMult, for reconstructing the sequence of copy number changes driving carcinogenesis, based on the analysis of several tumor samples from the same patient. We demonstrate the reliability of the method with simulated data, and describe applications to three different cancers, showing that TuMult is a valuable tool for the establishment of clonal relationships between tumor samples and the identification of chromosome aberrations occurring at crucial steps in cancer progression.

引用

页数：19

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