Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice

被引：13

作者：

Binaschi, A

Zucchini, S

Bregola, G

Rodi, D

Mazzuferi, M

Reinscheid, RK

Simonato, M

机构：

[1] Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, I-44100 Ferrara, Italy

[2] Univ Ferrara, Ctr Neurosci, I-44100 Ferrara, Italy

[3] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA

来源：

NEUROREPORT | 2003年 / 14卷 / 06期

关键词：

epilepsy; epileptogenesis; kindling; knock-out mice; nociceptin;

D O I：

10.1097/00001756-200305060-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide nociceptin/orphanin FQ (N/CFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigate its involvement in a chronic model of temporal lobe epilepsy, kindling epileptogenesis, using N/OFQ knock-out mice and their wild-type littermates as controls. Kindling development was retarded in N/ OFQ-deficient mice, in that (compared with controls) they required a significantly greater number of stimulations and a significantly longer time in electrical seizures to reach kindling criteria. These data indicate that N/OFQ is involved in the development of kindling and that it may play a pro-epileptogenic role.

引用

页码：825 / 827

页数：3

共 15 条

[1]

Bregola G, 2002, J NEUROSCI, V22, P10030

[2]

Cox B. M., 2000, IUPHAR COMPENDIUM RE, P321

[3] Orphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibition [J].