Repair of alveolar cleft defects: Reduced morbidity with bone marrow stem cells in a resorbable matrix

被引：92

作者：

Gimbel, Michael ^{[1
]}

Ashley, Rebekah K. ^{[1
]}

Sisodia, Manisha ^{[1
]}

Gabbay, Joubin S. ^{[1
]}

Wasson, Kristy L. ^{[1
]}

Heller, Justin ^{[1
]}

Wilson, Libby ^{[1
]}

Kawamoto, Henry K. ^{[1
]}

Bradley, James P. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA USA

来源：

JOURNAL OF CRANIOFACIAL SURGERY | 2007年 / 18卷 / 04期

关键词：

alveolar cleft defect; bone graft; iliac crest; tissue engineering; morbidity; donor site pain;

D O I：

10.1097/scs.0b013e3180a771af

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Harvest of the autogenous iliac crest bone graft for an alveolar cleft defect (the gold standard) may cause short- and long-term pain and sensory disturbances. To determine if a tissue engineering technique with similar bone healing results offered decreased morbidity, we compared techniques for postoperative donor site pain. Traditional iliac crest bone graft had more donor site complications compared with both tissue engineering and minimally invasive iliac crest bone graft. With donor site pain, traditional had the most patients with pain and tissue engineering had the least patients with pain at all time points. The mean pain score, including both intensity and pain frequency, was greatest at all time points in traditional and least at all time points in tissue engineering. Closure of alveolar cleft defects with a resorbable collagen sponge and bone marrow stem cells resulted in reduced donor site morbidity and decreased donor site pain intensity and frequency.

引用

页码：895 / 901

页数：7

共 26 条

[1]

SECONDARY BONE-GRAFTING OF ALVEOLAR CLEFTS - A SURGICAL-ORTHODONTIC TREATMENT ENABLING A NON-PROSTHODONTIC REHABILITATION IN CLEFT-LIP AND PALATE PATIENTS [J].