Failure of estrogen to protect the substantia nigra pars compacta of female rats from lesion induced by 6-hydroxydopamine

被引：32

作者：

Ferraz, AC

Xavier, LL

Hernandes, S

Sulzbach, M

Viola, GG

Anselmo-Franci, JA

Achaval, M

Da Cunha, C

机构：

[1] Univ Fed Parana, Dept Fisiol & Farmacol, Lab Fisiol & Farmacol Sistema Nervoso Cent, BR-81531990 Curitiba, Parana, Brazil

[2] Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Ciencias Morfol, Lab Histofisiol Comparada, BR-90050170 Porto Alegre, RS, Brazil

[3] Fac Odontol Ribeirao Preto, Dept Morfol Estomatol & Fisiol, BR-14040904 Ribeirao Preto, SP, Brazil

来源：

BRAIN RESEARCH | 2003年 / 986卷 / 1-2期

关键词：

neuroprotection; 6-hydroxydopamine; Parkinson's disease; estrogen; substantia nigra pars compacta;

D O I：

10.1016/S0006-8993(03)03198-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral. infusion of 6-hydroxydopamine (6-OHDA, 6 mug/side) was analyzed in ovariectomized adult female Wistar rats. Estrogen replacement for 52 days (400-mug 17-beta-estradiol capsules) did not prevent the loss of TH-immunoreactive cells induced by 6-OHDA in the SNpc. This result indicates that the neuroprotective effect of dopaminergic mesencephalic cells is not observed with long-term estrogen replacement. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：200 / 205

页数：6

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