The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

被引：864

作者：

Kadioglu, Aras ^{[1
]}

Weiser, Jeffrey N. ^{[2
]}

Paton, James C. ^{[3
]}

Andrew, Peter W. ^{[1
]}

机构：

[1] Univ Leicester, Dept Infect Immun & Imflammat, Leicester LE1 9HN, Leics, England

[2] Univ Penn, Dept Microbiol, Sch Med, Philadelphia, PA 19104 USA

[3] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 04期

关键词：

D O I：

10.1038/nrmicro1871

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an ability to evade the early components of the host immune response, this organism can spread from the upper respiratory tract to the sterile regions of the lower respiratory tract, which leads to pneumonia. In this Review, we describe how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease.

引用

页码：288 / 301

页数：14

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