Interleukin-10 abrogates the inhibition of Epstein-Barr virus-induced B-cell transformation by memory T-cell responses

被引：48

作者：

Bejarano, MT ^{[1
]}

Masucci, MG ^{[1
]}

机构：

[1] Karolinska Inst, Microbiol & Tumor Biol Ctr, S-17177 Stockholm, Sweden

来源：

BLOOD | 1998年 / 92卷 / 11期

关键词：

D O I：

10.1182/blood.V92.11.4256.423k12_4256_4262

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro infection of human B lymphocytes by Epstein-Barr virus (EBV) results in their growth transformation and establishment of immortalized lymphoblastoid cell lines. The virus was found to encode a homologue of the pleiotropic cytokine interleukin-10 (IL-10), which has wide-ranging effects on the immune system. We investigated the effect of human IL-10 (hIL-10) and viral IL-10 (vIL-10) on EBV-specific immunological memory, as assessed by the inhibition of EBV-induced B-cell transformation by the autologous T cells, We found that IL-10 abrogates the inhibitory capacity of T cells, This IL-10 effect is mediated through suppression of T-cell activation-induced IL-2 and interferon-gamma production and through a direct enhancement of EBV-infected B-cell growth. (C) 1998 by The American Society of Hematology.

引用

页码：4256 / 4262

页数：7

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