Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus

被引：23

作者：

Hassan, MK ^{[1
]}

AlNatour, MQ ^{[1
]}

Ward, LA ^{[1
]}

Saif, YM ^{[1
]}

机构：

[1] OHIO STATE UNIV, OHIO AGR RES & DEV CTR, FOOD ANIM HLTH RES PROGRAM, WOOSTER, OH 44691 USA

来源：

AVIAN DISEASES | 1996年 / 40卷 / 03期

关键词：

infectious bursal disease virus; pathogenicity; attenuation; immunogenicity;

D O I：

10.2307/1592265

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF chickens vaccinated with the attenuated IN virus used as a live or inactivated vaccine followed by homologous (IN) and heterologous (STC) challenge with bursa-derived viruses.

引用

页码：567 / 571

页数：5

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