Effects of Maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis

被引：59

作者：

Matsui, K ^{[1
]}

Kodama, N ^{[1
]}

Nanba, H ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Dept Microbial Chem, Higashinada Ku, Kobe, Hyogo 6588558, Japan

来源：

CANCER LETTERS | 2001年 / 172卷 / 02期

关键词：

angiogenesis; anti-tumor activity; Maitake D-Fraction;

D O I：

10.1016/S0304-3835(01)00652-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 198

页数：6

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