Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

被引：157

作者：

Quesenberry, Peter J. ^{[1
]}

Aliotta, Jason ^{[1
]}

Deregibus, Maria Chiara ^{[2
,3
]}

Camussi, Giovanni ^{[3
]}

机构：

[1] Brown Univ, Warren Alpert Med Sch, Dept Med, Providence, RI 02912 USA

[2] Univ Torino, Fresenius Med Care, Translat Ctr Regenerat Med, I-10126 Turin, Italy

[3] Univ Torino, Dept Med Sci, I-10126 Turin, Italy

来源：

STEM CELL RESEARCH & THERAPY | 2015年 / 6卷

基金：

美国国家卫生研究院;

关键词：

MESENCHYMAL STEM-CELLS; EXOSOME-MEDIATED TRANSFER; ACUTE TUBULAR INJURY; MESSENGER-RNA; INTERCELLULAR COMMUNICATION; STROMAL CELLS; MICROVESICLES PROTECT; HEPATIC REGENERATION; PREMETASTATIC NICHE; HORIZONTAL TRANSFER;

D O I：

10.1186/s13287-015-0150-x

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. Extracellular vesicles, which include exosomes and microvesicles, carry proteins, bioactive lipids, and nucleic acids, which are protected from enzyme degradation. These vesicles can transfer signals capable of altering cell function and/or reprogramming targeted cells. In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. The relevance of these phenomena in stem cell biology and tissue repair is discussed.

引用

页数：10

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