Rote of nonimmune IgG bound to PfEMP1 in placental malaria

被引：120

作者：

Flick, K

Scholander, C

Chen, QJ

Fernandez, V

Pouvelle, B

Gysin, J

Wahlgren, M

机构：

[1] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

[2] Swedish Inst Infect Dis Control, S-17177 Stockholm, Sweden

[3] Univ Aix Marseille 2, Fac Med, Unite Parasitol Expt, F-13385 Marseille 5, France

来源：

SCIENCE | 2001年 / 293卷 / 5537期

关键词：

D O I：

10.1126/science.1062891

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infections with Plasmodium falciparum during pregnancy lead to the accumulation of parasitized red blood cells (infected erythrocytes, IEs) in the placenta. IEs of A falciparum isolates that infect the human placenta were found to bind immunoglobulin G (IgG). A strain of P. falciparum cloned for IgG binding adhered massively to placental syncytiotrophoblasts in a pattern similar to that of natural infections. Adherence was inhibited by IgG-binding proteins, but not by glycosaminoglycans or enzymatic digestion of chondroitin sulfate A or hyaluronic acid. Normal, nonimmune IgG that is bound to a duffy binding-like domain beta of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) might at the IE surface act as a bridge to neonatal Fc receptors of the placenta.

引用

页码：2098 / 2100

页数：3

共 17 条

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