Biomonitoring Equivalents (BE) dossier for toluene (CAS No. 108-88-3)

Recent efforts by the US Centers for Disease Control and Prevention and other researchers have resulted in a growing database of measured concentrations of chemical substances in blood or urine samples taken from the general population. However, few tools exist to assist in the interpretation of the measured values in a health risk context. Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood urine or other,, medium) that is consistent with an existing health-based exposure guideline. This document reviews available pharmacokinetic data and models for toluene and applies these data and models to existing health-based exposure guidance values from the US Environmental Protection Agency, the Agency for Toxic Substances and Disease Registry, Health Canada, and the World Health Organization, to estimate corresponding BE values for toluene in blood. These values can be used as screening tools for evaluation of biomonitoring data for toluene in the context of existing risk assessments for toluene and for prioritization of the potential need for additional risk assessment efforts for toluene. (c) 2008 Elsevier Inc. All rights reserved.