Stimulation of cultured colon 26 cells with TNF-α promotes lung metastasis through the extracellular signal-regulated kinase pathway

被引：37

作者：

Choo, MK

Sakurai, H

Koizumi, K

Saiki, I

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Div Pathogen Biochem, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, 21st Century COE Program, Toyama 9300194, Japan

来源：

CANCER LETTERS | 2005年 / 230卷 / 01期

关键词：

tumor necrosis factor-alpha; metastasis; extracellular signal-regulated kinase; matrix metalloproteinase-9;

D O I：

10.1016/j.canlet.2004.12.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-a enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-a in vitro showed marked potential to metastasize to the lung and liver in vivo. U0126, an inhibitor of MEK1/2, inhibited the TNF-alpha-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and the metastatic properties in vitro without affecting cell proliferation. In addition, pretreatment with U0126 in vitro completely abrogated the increased lung metastasis of TNF-alpha-treated cells. These results indicate that TNF-a-induced activation of cancer cells through the ERK pathway is sufficient for the enhanced metastatic potential of colon 26 cells. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 56

页数：10

共 33 条

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