Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic restless legs syndrome: a resting-state functional magnetic resonance imaging study

被引：66

作者：

Liu, Chunyan ^{[1
,2
]}

Dai, Zhengjia ^{[3
,4
]}

Zhang, Ruihua ^{[5
]}

Zhang, Mo ^{[6
]}

Hou, Yue ^{[1
]}

Qi, Zhigang ^{[6
]}

Huang, Zhaoyang ^{[1
]}

Lin, Yicong ^{[1
]}

Zhan, Shuqin ^{[1
]}

He, Yong ^{[3
,4
]}

Wang, Yuping ^{[1
,2
]}

机构：

[1] Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing, Peoples R China

[2] Beijing Key Lab Neuromodulat, Beijing, Peoples R China

[3] Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning & IDG, Beijing 100875, Peoples R China

[4] Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China

[5] Capital Med Univ, Lu He Teaching Hosp, Dept Funct Neurol, Beijing, Peoples R China

[6] Capital Med Univ, Xuan Wu Hosp, Dept Radiol, Beijing, Peoples R China

来源：

SLEEP MEDICINE | 2015年 / 16卷 / 06期

基金：

中国国家自然科学基金;

关键词：

RLS; ALFF; rTMS; Resting-state functional MRI; Pathophysiology; Neuromodulation; MOTOR CORTEX; EXCITABILITY; MRI; INFORMATION; IMPACT; TASK; PAIN; FMRI;

D O I：

10.1016/j.sleep.2014.12.029

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: The objectives of this study were, first, to explore differences in brain activity between normal people and idiopathic restless legs syndrome (RLS) patients during asymptomatic periods; and, second, to determine whether administering repetitive transcranial magnetic stimulation (rTMS) to specific cortical regions would reverse any observed differences in brain activity and alleviate patient symptoms. Methods: Fifteen idiopathic RLS patients (nine drug-naive patients) and 14 gender-and age-matched healthy controls were enrolled. Resting-state functional magnetic resonance imaging was used to measure the amplitude of low-frequency fluctuations (ALFF) in spontaneous brain activity during asymptomatic periods. Seven patients received high-frequency (5 Hz) rTMS directed toward the leg area of the primary motor cortex. Scores on the International Restless Legs Syndrome Study Group (IRLSSG) Rating Scale and ALFF values were measured before and after treatment. Results: Compared with healthy controls, RLS patients showed lower ALFF in the sensorimotor and visual processing regions, and higher ALFF in the insula, parahippocampal and hippocampal gyri, left posterior parietal areas, and brainstem. These results were largely conserved when only drug-naive patients were considered. After rTMS treatment, ALFF in several sensorimotor and visual regions were significantly elevated and IRLSSG Rating Scale scores decreased, indicating improved RLS symptoms. Conclusions: High-frequency rTMS delivered to the leg area of the primary motor cortex may raise functional activity in the sensorimotor and occipital regions, leading to improve symptoms in RLS patients. These results provide novel insight into RLS pathophysiology and suggest a potential mechanism for rTMS therapy in idiopathic RLS patients. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：785 / 791

页数：7

共 36 条

[1]

Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology - A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health [J].