Pediatric clozapine intoxication

被引：26

作者：

Mady, S ^{[1
]}

Wax, P ^{[1
]}

Wang, D ^{[1
]}

Goetz, C ^{[1
]}

Hadley, C ^{[1
]}

Love, R ^{[1
]}

机构：

[1] UNIV ROCHESTER,DEPT EMERGENCY MED,ROCHESTER,NY 14627

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 1996年 / 14卷 / 05期

关键词：

pediatric; clozapine; ingestion; intoxication; antipsychotic; overdose; Clozaril; extrapyramidal symptoms; altered mental status;

D O I：

10.1016/S0735-6757(96)90152-7

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults, Clozapine's safety in children has not been established, This report describes three unintentional clozapine ingestions in pediatric patients, These are the first reported cases of clozapine intoxication in children, All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects, Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults, These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications. Copyright (C) 1996 by W.B. Saunders Company

引用

页码：462 / 463

页数：2

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