Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

被引：28

作者：

Dhanak, D ^{[1
]}

Christmann, LT ^{[1
]}

Darcy, MG ^{[1
]}

Keenan, RM ^{[1
]}

Knight, SD ^{[1
]}

Lee, J ^{[1
]}

Ridgers, LH ^{[1
]}

Sarau, HM ^{[1
]}

Shah, DH ^{[1
]}

White, JR ^{[1
]}

Zhang, LL ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Collegeville, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)00249-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1445 / 1450

页数：6

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